In the Madidi area and its zone of influence, sustainable livelihoods are promoted in communities, generating economic opportunities that strengthen traditional practices and incorporate innovative production techniques. Community enterprises in ecotourism, cacao, organic coffee and yacare caiman management received national and international awards for the development of quality products, the improvement of community income, and their conservation contributions.

Cacao crops grown in the wild or under agroforestry systems are produced by community members in the Tacana and Leco Larecaja indigenous territories and the municipality of Mapiri. Cacao beans are fermented and dried using innovative techniques that ensure a homogeneous and controlled process. Cacao production prevent the advance of the agricultural frontier and contribute to biodiversity conservation efforts.

The production of shade-grown organic coffee in the communities of the Teoponte municipality was awarded the 'Bird Friendly' seal by the Smithsonian Bird Migration Center for its contribution to the conservation of the habitat of 235 species of birds in the coffee plantations (16.6% of Bolivia's birds).

The use of the yacare caiman (Caiman yacare) is one of the most important natural resource use activities of the Tacana people, and is carried out using management plans and population censuses, ensuring the protection of the species. The initiative involves four communities settled on the Beni river and has benefited more than 90 indigenous families between 2007 and 2019.

The Tacana and Leco indigenous patios and gardens preserve a variety of crops including vegetables, fruits, spices, medicinal and ornamental plants, which ensure food for families and help improve their income by marketing opportunities at fairs and in restaurants. The Sabores Silvestres expeditions, promoted by WCS and the Gustu restaurant, identified vegetables from the orchards and forest fruits traditionally used by the indigenous communities, in addition to cocoa, paiche fish, and caiman meat, to incorporate them into La Paz restaurants, thus helping to preserve their cultural significance and their culinary and nutritional value.

Madidi is one of Bolivia's main tourism destinations because of its exceptional biological diversity and cultural richness. Community-based tourism initiatives strengthen the link between culture and nature. It is part of the Rurrenabaque-Madidi-Pampas Tourist Destination, which is certified as an international sustainable tourism destination by Biosphere.